Biology author Janine Benyus describes how nature can help medical science in her book Biomimicry* where she explains how we can learn from nature’s proteins. She describes the ingenious way mollusks use their proteins to generate strong calcium shells “…the mollusk releases templating proteins into the” ‘[‘inner rooms’.] “These proteins self assemble into a ‘wallpaper’ that peppers the room with an orderly array of negatively charged [calcium/carbonate ions]. Proteins (which make up 50 % of the dry weight of every living cell) are large 3-D molecules that began as long necklaces of dozens… of amino acids. Each amino acid has a different constellation of charges, and when the chain is released into the fluid of the cell those charges cause the protein to fold up in a very particular way…. what results is a three dimensional shape , a form uniquely suited to its function. A protein may have a structural role in the body, assembling into tissues and skeleton, or it may have a ‘trade’. Hemoglobin, insulin, neuron receptors , antibodies and enzymes ….are all proteins plying a particular trade based on their shape.” Now her book describes many examples of how to mimic nature to aid biosynthetic design including drug design. GGF Codeweaver takes the profile or profiles of a protein sub unit from nature and generates the theoretical DNA sequence that made that protein sub unit. It does this by reversing the GGF Geneseeker algorithm in a multi stage inverse algorithm using the GGF logic of DNA and various amino acid and codon schemes. If the molecule that GGF is trying to mimic has use in a medical or industrial setting then that molecule might form the basis for a peptide in a clinical setting or anindustrial enzyme. Some researchers have discovered proteins from nature of medical interest which they have synthesized for their intended purpose. A good example is the research done by the University of Queensland (UQ). UQ has a world class facility of molecular biology focusing on anti venom which includes an auditorium sized nuclear resonance mass spectrometer able to provide profiles of proteins of interest. A protein developed from funnel web spider venom may delay damage from stroke up to 8 hours after the stroke. Moreover, the Victor Chang institute’s supply of donor hearts may benefit from this protein by prolonging donor heart lives (3 out 4 donor hearts may not survive to implant). On a wider scope the core work of UQ’s  Institute of Molecular Science /Gehrman Institute’s work on anti venom is of great interest to medical science as this quote indicates:  [The complexity of venom toxins] “makes venom attractive to scientists seeking to understand how the human body works.  They can use it to tweak the body’s internal machinery to correct problems, fight disease and improve health.  That’s because our bodies …have an astonishing galaxy of components – from multitudes of proteins and enzymes, fatty acids like lipids, vitamins, salts such as sodium and potassium, trace elements and signalling molecules that all interact with each other, under the control of genes.”  Australian Geographic -Jan-Feb 2021.p68.     One example that has given UQ a lead project is the funnel web spider whose venom contains up to 3000 peptides – an astonishing array of potential molecules for possible use. Professor Glenn King of the UQ institutes presented his work on television recently. There are a number of other examples of drugs developed from venoms such as ziconotide developed from the venom of a cone snail to treat chronic pain.

* J.M. Benyus, Biomimicry – Innovation Inspired By Nature (1997) William Morrow-Harper Collins pp102-103

GGF potential contribution

Here the GGF Codeweaver presents good synergy with these projects.  These venoms are ‘black boxes’ in that researchers really do not know how they fully work but realize  they contain a cocktail of proteins (peptides/enzymes) such as Australia’s own Funnel Web  spider with 3000 compounds. Now the holy grail for anti venom researchers is a polyvalent anti venom  to help the over 5 million people who are bitten by all creatures on this earth each year (80,000 to 130,000 deaths pa) and already they do have some polyvalent anti venoms.  CSL subsidiary Seqiris, a flu vaccine producer, already produces polyvalent anti venoms at its facility in Queensland harvesting them from horse plasma.

The GGF Codeweaver could be set to work to take moulds of the profiles of these mysterious proteins in venoms and reverse engineer the DNA sequence that encodes aptamers mimicking the shapes of these proteins and in the process target universal ‘swiss army knife’ polyvalent compound medicines to improve health outcomes and even save lives.  The Codeweaver algorithm can provide arrays of candidate peptides widening the possibilities for anti venom medical researchers and drug developers.

Another example of biomimicry involves a protein from a fish

The Victor Chang institute has made a major discovery concerning Zebra fish and its ability to repair its heart , kidneys and spine using a protein KLF1. If KLF1 can be put into a drug form it could repair damage to the heart after heart attacks.

The GGF Codeweaver may be able to mimic or model the protein by generating GGF peptides moulded to the KLF1 protein. Utilizing the GGF Codeweaver algorithm the profile of KLF1 can be processed to produce alternative biologic molecules to mimic KLF1 to replace, supplement it or act as a complementary filler to enhance efficacy or sustain less side effects by reducing toxicity such as we aim to do by designing a harmless oncolytic virus carrier to deliver the low toxicity GGF peptide.